解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence pro-inflammatory cell function. To investigate whether tenidap can modulate cellular responses to cytokine stimulatio...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.1027
更新日期:1995-02-01 00:00:00
abstract::TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.1002
更新日期:1995-01-01 00:00:00
abstract::KYM-1D4 cells are a subline derived from a human rhabdomyosarcoma which are highly sensitive to TNF-mediated cytotoxicity. They were selected for this study because they express human TNF-R and are therefore a more relevant target for comparing the potential therapeutic value of human TNF-inhibitory agents than the us...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90049-3
更新日期:1994-11-01 00:00:00
abstract::The production of nitric oxide (NO) is increased in experimental nephritis, with NO thought to be an important mediator of cell damage. The cytokines interleukin 1 beta (IL-1 beta), IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1) and transforming growth factor-beta (TGF-beta) are released from mesangial cells in vi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90047-7
更新日期:1994-11-01 00:00:00
abstract::We have examined basal and lipopolysaccharide (LPS)-induced release of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor-alpha (TNF-alpha) and soluble CD14 (sCD14) in whole blood and peripheral blood mononuclear cells (PBMC) from 20 persons with either high (1.62-2.47 m...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90080-9
更新日期:1994-09-01 00:00:00
abstract::To clarify the biological significance of tumour necrosis factor alpha (TNF-alpha) precursor, we analysed its expression at the primed and triggered stages using human monocyte-like cell line THP-1. To prime them, THP-1 cells were treated with either recombinant human interferon gamma (rIFN-gamma) or recombinant human...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90056-6
更新日期:1994-07-01 00:00:00
abstract::The human interferon alpha-receptor (IFNAR gene product or IFN alpha R protein) was expressed in hamster CHO cells and in mouse A9 cells. The response of the IFN alpha R cDNA transfectants to human IFNs was studied by measuring induction of (2'-5') A synthetase (2'-5' AS). In the murine cells, the IFN alpha R protein ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90066-3
更新日期:1994-07-01 00:00:00
abstract::Cytokine induction following stimulation by endotoxin (LPS) was investigated in human peripheral whole blood. Blood cells were suspended in autologous plasma diluted in basal medium (BM-plasma) or Compound Sodium Lactate Solution (CSL-plasma), or in autologous serum diluted in CSL. Induction of interleukin 1 beta, int...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90020-5
更新日期:1994-05-01 00:00:00
abstract::Expression of cytokine genes, TNF-alpha, TNF-beta and IFN-gamma, in human astroglial cell lines and in fresh brain specimens was studied by PCR. mRNA transcripts of TNF-alpha could be detected in three out of five astrocytomas and neuroblastoma cell lines, and after stimulation with IL-1 beta/IFN-gamma or LPS/IFN-gamm...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90039-6
更新日期:1994-03-01 00:00:00
abstract::Cytokine mRNA expression was analyzed by reverse transcriptase (RT)/PCR in extensively purified normal peripheral CD4+CD45R T cell subsets. Both CD45RA+ and CD45 RO+ populations produced mRNAs for interleukin (IL)-2, IL-2 receptor (alpha chain), IL-6 receptor and tumour necrosis factor (TNF)-beta within 3-4 h of activ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90032-9
更新日期:1994-03-01 00:00:00
abstract::The present study was aimed at defining the activity of human and mouse monocyte chemotactic protein-1 (MCP-1) on homologous and heterologous mononuclear phagocytes. Human natural and recombinant MCP-1 and mouse natural MCP-1/JE were tested as chemoattractants on human blood monocytes and mouse peritoneal macrophages....
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90004-3
更新日期:1994-01-01 00:00:00
abstract::A simple, generally applicable method to incorporate cytokine proteins into multilamellar liposomes is presented. A variety of human cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukins 1 alpha, 2 and 6 (IL-1 alpha, IL-2, IL-6) and interferon-gamma (IFN-gamma) were incorporated i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90014-0
更新日期:1994-01-01 00:00:00
abstract::The predominant pathological features in the central nervous system (CNS) in multiple sclerosis (MS) are perivascular inflammation and demyelination. The cells in the inflammatory cuff consist mainly of T lymphocytes and macrophages. Cytokines produced by inflammatory cells within the CNS have the potential to enhance...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(05)80008-0
更新日期:1993-11-01 00:00:00
abstract::Interleukin 6 (IL-6) stimulates fibrinogen (Fg) gene expression both in vivo and in vitro; while interleukin 1 (IL-1) paradoxically stimulates in vivo, yet inhibits in vitro, Fg synthesis. The naturally occurring interleukin 1 receptor antagonist (IL-1ra) and passive immunization with anti-IL-6 antiserum were used to ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90035-4
更新日期:1993-09-01 00:00:00
abstract::Paraquat (PQ) is a herbicide which is highly pneumotoxic by generating reactive oxygen intermediates (ROI). Pro-inflammatory cytokines, particularly IL-1 and TNF, have been implicated in some ROI-mediated pathologies, including bleomycin toxicity and ischaemia/reperfusion injury. We have studied the effect of PQ on th...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90045-7
更新日期:1993-09-01 00:00:00
abstract::During T-lymphocyte differentiation in the thymus, the majority of thymocytes die by apoptosis in situ. This process is characterized by internucleosomal DNA fragmentation and is induced by a number of stimuli including glucocorticoids, calcium ionophore, cAMP and 12-o-tetradecanoylphorbol 13-acetate (TPA). In this st...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90066-e
更新日期:1993-07-01 00:00:00
abstract::The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated. IL-1 alpha had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP; it significantly reduced mortality of mice and decreased serum transaminase level. The maxi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90004-o
更新日期:1993-05-01 00:00:00
abstract::Antibiotic therapy is only moderately efficacious for bovine Staphylococcus aureus mastitis. We have used recombinant bovine cytokines to activate the natural host defenses, to prevent and treat bovine mastitis. Uninfected mammary glands infused with GM-CSF or IL-2 increased the percentage of phagocytic cells in the m...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90015-w
更新日期:1993-05-01 00:00:00
abstract::The effect of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and insulin-like growth factor-1 (IGF-1) on the cytostatic activity of tumour necrosis factor-alpha (TNF-alpha) was studied on the breast cancer cell line, T47D. TNF-alpha completely blocked the potent growth-promoting activity of all t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90056-b
更新日期:1993-03-01 00:00:00
abstract::The induction of cytokine secretion by human peripheral blood (PB) T cells was examined. Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. In contrast, induction of ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(92)90006-d
更新日期:1992-11-01 00:00:00
abstract::Rheumatoid arthritis (RA) is an immune disease in which the pathological immune reaction is thought to be initiated by the presentation of an (auto) antigen or superantigen by MHC class II positive cells to CD4 T cells. These successive immunological events can be studied by the cytokines produced at the different sta...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(92)90021-i
更新日期:1992-11-01 00:00:00
abstract::Typically, ovarian cancer remains restricted to the peritoneal cavity. Because of this unique localization, the study of ovarian cancer is particularly suitable for immune analysis and for the development of immunotherapy. Here we report that peritoneal fluid from patients with ovarian or other intra-abdominal cancers...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(92)90082-3
更新日期:1992-09-01 00:00:00
abstract::Interactions between interleukin 8 (IL-8) and endothelial cells play an important role in the emigration of mononuclear cells from the blood into areas of inflammation. We examined the ability of specific second-line antirheumatic drugs to regulate (IL-8) gene expression and protein secretion in interleukin 1 (IL-1) s...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(92)90085-6
更新日期:1992-09-01 00:00:00
abstract::In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(92)90066-z
更新日期:1992-07-01 00:00:00
abstract::Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90047-h
更新日期:1991-09-01 00:00:00
abstract::The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90498-3
更新日期:1991-07-01 00:00:00
abstract::Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90500-d
更新日期:1991-07-01 00:00:00
abstract::Human interleukin-6 (IL-6) secreted by cytokine- or endotoxin-induced fibroblasts, monocytes, keratinocytes, endometrial stromal cells, and endothelial cells, when analyzed under denaturing and reducing conditions, consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90018-9
更新日期:1991-05-01 00:00:00
abstract::In this study we have examined the effect of agents known to perturb certain signal transduction pathways on the biological responses of target cells to stimulation with interleukin-1 (IL-1). In the murine thymoma cell line EL4, IL-1 stimulation results in the secretion of interleukin-2 (IL-2), which was subsequently ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90009-3
更新日期:1991-01-01 00:00:00
abstract::The purpose of these studies was to test whether pentoxifylline, a drug that can inhibit the production and action of cytokines hypothesized to be endogenous pyrogens (for example, interleukin 1 and tumor necrosis factor [TNF]), is antipyretic. We also tested the effects of pentoxifylline on plasma activities of inter...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(90)90032-o
更新日期:1990-07-01 00:00:00
abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates production of neutrophils in bone marrow and may decrease the incidence of infection during neutropenia. We evaluated the protective role of recombinant GM-CSF against Pseudomonas aeruginosa challenge in neutropenic mice. CD-1 mice treated with cyclo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(90)90030-w
更新日期:1990-07-01 00:00:00
abstract::Although tumor necrosis factor (TNF) and interleukin 6 (IL 6) are purported to be important mediators of inflammatory responses following trauma, it is not known if the serum levels of these cytokines are altered by simple hemorrhage. The objective of this study therefore was to determine whether or not: 1) there is a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(90)90012-i
更新日期:1990-05-01 00:00:00
abstract::The effect of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) on the expression of HLA-DR, and the production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) by human peripheral blood monocyte-enriched populations was investigated. GM-CSF was shown to induc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(90)90044-t
更新日期:1990-01-01 00:00:00
abstract::Most studies have shown that interleukin-1 (IL-1) acts as a helper or co-stimulator in T-lymphocyte activation and proliferation by mitogens or antigens. We describe here a stable subclone (D10S) of the murine D10.G4.1 helper T-cell which proliferates to subfemtomolar (attomolar) concentrations of IL-1 beta or alpha i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(89)91044-2
更新日期:1989-11-01 00:00:00